Two sample MR report
RPS26_Interstitial Macrophages against UKB-b-18436
Date: 13 January, 2026
Results from two sample MR:
| method | nsnp | b | se | pval |
|---|---|---|---|---|
| MR Egger | 4 | -0.0662173 | 0.2022718 | 0.7744793 |
| Weighted median | 4 | -0.0593497 | 0.0132117 | 0.0000070 |
| Inverse variance weighted | 4 | -0.0602588 | 0.0114372 | 0.0000001 |
| Simple mode | 4 | -0.0581939 | 0.0174036 | 0.0442630 |
| Weighted mode | 4 | -0.0582513 | 0.0177292 | 0.0462303 |
Heterogeneity tests
| method | Q | Q_df | Q_pval |
|---|---|---|---|
| MR Egger | 0.0556910 | 2 | 0.9725386 |
| Inverse variance weighted | 0.0565616 | 3 | 0.9964824 |
Test for directional horizontal pleiotropy
| egger_intercept | se | pval |
|---|---|---|
| 0.0031007 | 0.1050906 | 0.9791412 |
Test that the exposure is upstream of the outcome
| snp_r2.exposure | snp_r2.outcome | correct_causal_direction | steiger_pval |
|---|---|---|---|
| 0.0002024 | 0 | TRUE | 0.1808611 |
Note - R^2 values are approximate
Forest plot of single SNP MR
Comparison of results using different MR methods
Funnel plot
Leave-one-out sensitivity analysis
